Evaluation of antiurolithitic activity of ethanolic extract of Cyperus rotundus Linn. rhizome. The antiurolithiatic was activity experimentally evaluated by using poly ethylene glycol (0.75% v/v) induced rats for 28 days. The level of various urolithiatic promoters in the biological samples (urine, serum and kidney homogenate) renal function and histopathology were used as criteria for assessing the antiurolithiatic effect of EECR at a dose of 750 mg/kg produce wistar rats were divided in 4 group (n=6) control, disease control, standard and test. In ethylene glycol induced urolithatic model, EECR showed significant diseases excretion and deposition of various urolithiatic promoters (calcium, oxalate, phosphate and uric acid) as compared to urolithiatic control (p<0.05). EECR also decreased serum concentration of urea, uric acid and creatinine as compared to urolithiatic control (p<0.01). The present study showed that the antiurolithiatic activity of EECR may be mainly due to its diuretic activity. The presence of phytoconstituents like flavanoids, saponins and terpenoids in EECR might be responsible for its antiurolithatic potency of Cyperus rotundus.
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